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GGTC German Gene Trap Consortium

 

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 publications

 

Schnutgen F, Hansen J, De-Zolt S, Horn C, Lutz M, Floss T, Wurst W, Noppinger PR, von Melchner H.
Enhanced gene trapping in mouse embryonic stem cells
Nucleic Acids Res 2008 November; 36(20): e133

 

 

Horn C, Hansen J, Schnutgen F, Seisenberger C, Floss T, Irgang M, De-Zolt S, Wurst W, von Melchner H, Noppinger PR.
Splinkerette PCR for more efficient characterization of gene trap events
Nat Genet. 2007 Aug;39(8):933-4

 

 

Hitz C, Vogt-Weisenhorn D, Ruiz P, Wurst W, Floss T.
Progressive loss of the spongiotrophoblast layer of Birc6/Bruce mutants results in embryonic lethality.
Genesis. 2005 Jun;42(2):91-103. Erratum in: Genesis. 2005 Dec;43(4):216.

 

 

De-Zolt S, Schnutgen F, Seisenberger C, Hansen J, Hollatz M, Floss T, Ruiz P, Wurst W, von Melchner H.
High-throughput trapping of secretory pathway genes in mouse embryonic stem cells.
Nucleic Acids Res. (2006) 34(3):e25.

 

 

Schnutgen F, De-Zolt S, Van Sloun P, Hollatz M, Floss T, Hansen J, Altschmied J, Seisenberger C, Ghyselinck NB, Ruiz P, Chambon P, Wurst W, von Melchner H.
Genomewide production of multipurpose alleles for the functional analysis of the mouse genome.
Proc Natl Acad Sci USA. 2005 102(20):7221-7226.

 

 

Cecile Martinat, Shoshana Shendelman, Alan Jonason, Thomas Leete, M. Flint Beal, Lichuan Yang, Thomas Floss, Asa Abeliovich.
Sensitivity to Oxidative Stress in DJ-1-Deficient Dopam ine Neurons: An ES-Derived Cell Model of Primary Parkinsonism.
PLoS Biology, Nov 2004, Volume 2, Issue 11, e327

 

 

The European Mouse Mutagenesis Consortium: 
Johan Auwerx, Phil Avner, Richard Baldock, Andrea Ballabio, Rudi Balling, Mariano Barbacid, Anton Berns, Allan Bradley, Steve Brown, Peter Carmeliet, Pierre Chambon, Roger Cox, Duncan Davidson, Kay Davies, Denis Duboule, Jiri Forejt, Francesca Granucci, Nick Hastie, Martin Hrabé de Angelis, Ian Jackson, Dimitris Kioussis, George Kollias, Mark Lathrop, Urban Lendahl, Marcos Malumbres, Harald von Melchner, Werner Müller, Juha Partanen, Paola Ricciardi-Castagnoli, Peter Rigby, Barry Rosen, Nadia Rosenthal, Bill Skarnes, A Francis Stewart, Janet Thornton, Glauco Tocchini-Valentini, Erwin Wagner, Walter Wahli & Wolfgang Wurst.
The European dimension for the mouse genome mutagenesis program.
Nature Genetics 36, 925-927, Sep 2004

 

 

The Comprehensive Knockout Mouse Project Consortium:
Christopher P Austin, James F Battery, Allan Bradley, Maja Bucan, Mario Capecchi, Francis S Collins, William F Dove, Geoffrey Duyk, Susan Dymecki, Janan T Eppig, Franziska B Grieder, Nathaniel Heintz, Geoff Hicks, Thomas R Insel, Alexandra Joyner, Beverly H Koller, K C Kent Lloyd, Terry Magnuson, Mark W Moore, Andras Nagy, Jonathan D Pollock, Allen D Roses, Arthur T Sands, Brian Seed, William C Skarnes, Jay Snoddy, Philippe Soriano, David J Stewart, Francis Stewart, Bruce Stillman, Harold Varmus, Lyuba Varticovski, Inder M Verma, Thomas F Vogt, Harald von Melchner, Jan Witkowski, Richard P Woychik, Wolfgang Wurst, George D Yancopoulos, Stephen G Young, Brian Zambrowicz.
The Knockout Mouse Project.
Nature Genetics 36, 921-924, Sep 2004

 

 

Skarnes WC, von Melchner H, Wurst W, Hicks G, Nord AS, Cox T, Young SG, Ruiz P, Soriano P, Tessier-Lavigne M, Conklin BR, Stanford WL, Rossant J; International Gene Trap Consortium. (2004):

A public gene trap resource for mouse functional genomics.

Nat Genet. 2004 Jun; 36(6):543-4.

 

 

Ihalmo P, Rinta-Valkama J, Mai P, Astrom E, Palmen T, Pham TT, Floss T, Holthofer H (2004):

Molecular cloning and characterization of an endogenous antisense transcript of Nphs1.

Genomics. 2004 Jun; 83(6):1134-40.

 

 

Istvanffy R., Vogt-Weisenhorn D.M., Floss T., Wurst W. (2004):

Expression of neurochondrin in the developing and adult mouse brain.

Dev Genes Evol. 2004 Apr; 214(4):206-9.

 

 

Hansen J., Floss T., Van Sloun P., Fuechtbauer E.-M., Vauti F., Arnold H.-H., Schnütgen F., Wurst W., von Melchner H., Ruiz P. (2003):

A large scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.

PNAS 100: 9918-9922.

 

 

Francois Spitz, Federico Gonzalez and Denis Duboule.
A Global Control Region Defines a Chromosomal Regulatory Landscape Containing the HoxD Cluster.
Cell, Vol. 113, 405–417, May 2, 2003

 

 

Sterner-Kock A., Thorey I. S., Koli K., Wempe F., Otte J., Bangsow T., Kuhlmeier K., Kirchner T., Jin S., Keski-Oja J., von Melchner H. (2002):

Disruption of the gene encoding the latent transforming growth factor- binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancer.

Genes Dev 16: 2264-2273.

 

 

Rantanen M., Palmen T., Patari A., Ahola H., Lehtonen S., Astrom E., Floss T., Vauti F., Wurst W., Ruiz P., Kerjaschki D., Holthofer H. (2002):

Nephrin TRAP mice lack slit diaphragms and show fibrotic glomeruli and cystic tubular lesions.

J Am Soc Nephrol 13(6): 1586-94.

 

 

Floss T., Uez N., Frey S., Wurst W. (2002):

Genotpying gene trap mutant mice by real-time PCR.

Genotyping gene-trap mutant mice by real-time PCR 

 

 

Floss T. and Wurst W. (2002):

Functional genomics by gene-trapping in embryonic stem cells. In: K. Turksen (ed.) Methods in Molecular Biology, vol. 185. Embryonic Stem Cells : Methods and Protocols.

Humana Press Inc., Totowa, New Jersey, 347-379.

 

 

Gebauer M, von Melchner H, Beckers T. (2001):

Genomewide trapping of genes that encode secreted and transmembrane proteins repressed by oncogenic signaling. locus.

Genome Res. 11(11):1871-7.

 

 

Mainguy G, Luz Montesinos M, Lesaffre B, Zevnik B, Karasawa M, Kothary R, Wurst W, Prochiantz A, Volovitch M. (2000):

An induction gene trap for identifying a homeoprotein-regulated locus.

Nat Biotechnol 18(7):746-749.

 

 

Wurst W and Gossler A (2000):

Gene trap strategies in ES cells. In: A. Joyner (ed.): "Gene Targeting", A practical approach, 2nd edition.

Oxford University Press.

 

 

Wiles MV, Vauti F, Otte J, Fuchtbauer EM, Ruiz P, Fuchtbauer A, Arnold HH, Lehrach H, Metz T, von Melchner H, Wurst W. (2000):

Establishment of a gene-trap sequence tag library to generate mutant mice from embryonic stem cells.

Nat Genet 24(1):13-4.

 

 

Sam M, Wurst W, Kluppel M, Jin O, Heng H, Bernstein A. (1998):

Aquarius, a novel gene isolated by gene trapping with an RNA-dependent RNA polymerase motif.

Dev Dyn 212(2):304-17.

 

 

Forrester LM, Nagy A, Sam M, Watt A, Stevenson L, Bernstein A, Joyner AL, Wurst W. (1996):

An induction gene trap screen in embryonic stem cells: Identification of genes that respond to retinoic acid in vitro.

Proc Natl Acad Sci USA 93(4):1677-82.

 

 

Wurst W, Rossant J, Prideaux V, Kownacka M, Joyner A, Hill DP, Guillemot F, Gasca S, Cado D, Auerbach A, et al. (1995):

A large-scale gene-trap screen for insertional mutations in developmentally regulated genes in mice.

Genetics 139(2):889-99.

 

Hill, D.P. and W. Wurst (1993):

Gene and enhancer trapping: mutagenic strategies for developmental studies.

Curr Top Dev Biol 28:181-206.

 

 

von Melchner H, DeGregori JV, Rayburn H, Reddy S, Friedel C, Ruley HE. (1992):

Selective disruption of genes expressed in totipotent embryonal stem cells.

Genes Dev 6(6):919-27.

 

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